Diseases are negative conditions that are contracted from enemy attacks, curios, traps, and occasionally as a random quirk at the end of a dungeon. You can only get a disease at the end of a dungeon if your hero's resolve level is at least 2. If it is, the chance of getting a disease is 32% - 0.33 * disease resist but at least 5%. Althought most of the diseases are harmful, Rabies is quite beneficial because it grants +15% DMG while only reducing -10 ACC. You can get it while fighting Rabid Gnashers.
A Leper contracting a disease.
They last until removed. They can be cured in the Sanitarium for some gold (where there is a chance of multiple diseases being cured at once depending on upgrade level) or by using the right camping skills from the Grave Robber or the Plague Doctor (which will cure all the diseases on the targeted hero).
A hero can have at most 3 disease at once, if they acquire a new one it replaces an old disease picked at random.
List of diseases
| Disease name | Effect |
|---|---|
| Bad Humors | -20% Max HP |
| Black Plague | -75% Blight Resist
-75% Disease Resist -10% Max HP -5 SPD |
| Bulimic | -20% Heal Skills while Camping |
| Creeping Cough | -20% DMG |
| Ennui | -25% Virtue Chance |
| Griping in the Guts | -20% Heal Skills while Camping |
| Hemophilia | -20% Bleed Resist |
| Hysterical Blindness | -20 ACC if Stress above 70 |
| Lethargy | -4 SPD |
| Rabies | -10 ACC
+15% DMG |
| Scurvy | -40% Bleed Resist
-40% Move Resist |
| Spasm of the Entrails | -20% Healing Skills while camping |
| Spotted Fever | -50% Blight Resist |
| Syphilis | -5 ACC
-10% DMG -10% Max HP |
| Tapeworm | +100% Food Consumed
Chances of forced interaction with food curios. |
| Tetanus | -5 ACC
-5% CRT |
| The Ague | -10% DMG
-3 SPD -10% Max HP |
| The Fits | +3 SPD
-5 ACC -5% CRT |
| The Red Plague | -75% Bleed Resist
-10% Max HP -5% CRT |
| The Runs | -10% Max HP
-20 Dodge |
| The Worries | +30% Stress Damage |
| Vertigo | -50% Move Resist |
| Vampiric Spirits | -50% Debuff Resist |
| Wasting Sickness | -50% Disease Resistance |
List of attacks that can cause diseases
| Name | Monster | Attacks | Disease | Chance |
|---|---|---|---|---|
| Ghoul | 
|
Howl | The Worries | 5% |
| Maggot | 
|
Grave Nibble | Any | 15% |
| Swine Wretch | 
|
Vomit | Any | 33% |
| Carrion Eater | 
|
Munch | Any | 7% (Veteran) 9% (Champion) |
| Fungal Artillery | 
|
Rain of Blight | Any | 15% |
| Rabid Gnasher | 
|
Rabid Rush | Rabies | 10% |
| Crone | 
|
Fetid Censer | Any | 7% (Veteran) 9% (Champion) |
| Sea Maggot | 
|
Brine | Any | 8% |
| Deep Stinger | 
|
Salty Gouge Shocker |
Any
Any |
6%
6% |
| The Shrieker | 
|
Regurgitate | Any | 15% |
List of Curios that can cause diseases
| Name | Curio | Disease | Chance |
|---|---|---|---|
| Decorative Urn | 
|
Creeping Cough
Any |
7.4%
3.7% |
| Iron Maiden | 
|
Tetanus
Any |
13.3%
6.7% |
| Dinner Cart | 
|
Any | 25% |
| Makeshift Dining
Table |
|
Any | 25% |
| Pile of Bones | 
|
Any | 25% |
| Beast Carcass | 
|
Rabies | 28.6% |
| Shallow Grave | 
|
Any | 50% |
| Bas-Relief | 
|
Any | 8.3% |
| Brackish Tide Pool | 
|
Any | 25% |
| Fish Carcass | 
|
The Red Plague | 16.7% |
Trivia
The Carrion Eater and Crone have the only effects that increase Disease chance at higher levels.