Disease

Diseases are negative conditions that are contracted from enemy attacks, curios, traps, and occasionally as a random quirk at the end of a dungeon. You can only get a disease at the end of a dungeon if your hero's resolve level is at least 2. If so, the chance of getting a disease is 32% - 0.33 * disease resist but at least 5%.

Effects

Although most of the diseases are harmful, Rabies is quite beneficial because it grants +15% DMG while only reducing -10 ACC. You can get it while fighting Rabid Gnashers. The Fits and Grey Rot can also be useful on the Occultist and Vestal, as the +3 SPD it adds can be more useful than the lost ACC, CRT or DMG, especially given that healing skills are not affected by Crit chance.

Diseases last until removed. They can be cured in the Sanitarium for some gold (where there is a chance of multiple diseases being cured at once depending on upgrade level) or by using the right camping skills from the Grave Robber or the Plague Doctor (which will cure all the diseases on the targeted hero). Additionally, the Flagellant can cure one of his own diseases, not the other characters, with one of his camping skills.

A hero can have at most 3 diseases at once; if they acquire a new one, it replaces an old disease picked at random.

List of diseases

Disease name	Effect
Bad Humors	-20% Max HP
Black Plague	-75% Blight Resist -75% Disease Resist -10% Max HP -5 SPD
Bulimic	-20% Heal Skills while Camping
Creeping Cough	-20% DMG
Ennui	-25% Virtue Chance
Grey Rot	+20% Max HP -10 ACC -10% DMG
Hemophilia	-50% Bleed Resist
Hysterical Blindness	-20 ACC if Stress above 70
Lethargy	-4 SPD
Rabies	-10 ACC +15% DMG
Scurvy	-40% Bleed Resist -40% Move Resist
Sky Taint	+20% Stress -20% Bleed Resist -20% Blight Resist
Spasm of the Entrails	-20% Heal Skills while Camping
Spotted Fever	-50% Blight Resist
Syphilis	-5 ACC -10% DMG -10% Max HP
Tapeworm	+100% Food Consumed Chance of forced interaction with food curios. Chance to Steal / Keep (similar to Kleptomaniac) looted food.
Tetanus	-5 ACC -5% CRT
The Ague	-10% DMG -3 SPD -10% Max HP
The Fits	+3 SPD -5 ACC -5% CRT
The Red Plague	-75% Bleed Resist -10% Max HP -5% CRT
The Runs	-10% Max HP -20 Dodge
The Worries	+30% Stress Damage
Vertigo	-50% Move Resist
Vampiric Spirits	-50% Debuff Resist
Wasting Sickness	-50% Disease Resistance

List of attacks that can cause diseases

Name	Attacks	Disease	Chance
Ghoul	Howl	The Worries	5%
Maggot	Grave Nibble	Any	15%
Swine Wretch	Vomit	Any	33%
Carrion Eater	Munch	Any	7% (Veteran) 9% (Champion)
Fungal Artillery	Rain of Blight	Any	15%
Rabid Gnasher	Rabid Rush	Rabies	10%
Crone	Fetid Censer	Any	7% (Veteran) 9% (Champion)
Sea Maggot	Brine	Any	8%
Deep Stinger	Salty Gouge Shocker	Any Any	6% 6%
The Shrieker	Regurgitate	Any	15%
Thing From The Stars	Phase Gnaw	Sky Taint	20% (Apprentice) 22% (Veteran) 25% (Champion)

List of Curios that can cause diseases

Name	Disease	Chance
Decorative Urn	Creeping Cough Any	7.4% 3.7%
Iron Maiden	Tetanus Any	13.3% 6.7%
Dinner Cart	Any	25%
Makeshift Dining Table	Any	25%
Pile of Bones	Any	25%
Beast Carcass	Rabies	28.6%
Shallow Grave	Any	50%
Bas-Relief	Any	8.3%
Brackish Tide Pool	Any	25%
Fish Carcass	The Red Plague	16.7%

The Crimson Curse

The Crimson Court DLC adds a new disease known as the Crimson Curse. Usually it can only be contracted by fighting Bloodsucker enemies, and it has several unique properties, such as conferring debuffs that get worse over time. Any character with the curse cannot have any other diseases, and any disease they had will be removed upon acquiring the curse.